Novel MKPV—prevalence of over 15% .

A newly discovered, novel parvovirus genetically divergent from MVM and MPV that causes clinical disease in immunocompromised mice. Testing of random samples indicates a prevalence of over 15%.

MKPV infects both immunocompetent and immunodeficient mice causing inclusions in the renal tubular epithelium

In severely immunodeficient mice: MKPV causes an inclusion body nephropathy and in middle aged mice this leads to:

  • Chronic renal disease

  • Elevated BUN and creatinine 

  • Weight loss 

  • Death

  • Transmitted to naïve mice by co-housing or dirty bedding transfer

  • In random sampling of feces from immunodeficient and immunocompetent mice we found 15.5 % of samples positive.

  • Mice of multiple genetic lineages tested positive, including outbred stocks, inbred strains, and immunocompromised mice.


IDEXX BioAnalytics has developed a PCR-based, MKPV assay for detection .

 
  •  MKPV can be added to any profile upon request or ordered as a stand-along PCR test

  • A serologic assay for MKPV detection is under development

 

Sample types for PCR detection.

  • Feces from the cage

  • Urine

  •  Serum

  •  Kidney 

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