Novel MKPV—prevalence of over 15% .
A newly discovered, novel parvovirus genetically divergent from MVM and MPV that causes clinical disease in immunocompromised mice. Testing of random samples indicates a prevalence of over 15%.
MKPV infects both immunocompetent and immunodeficient mice causing inclusions in the renal tubular epithelium
In severely immunodeficient mice: MKPV causes an inclusion body nephropathy and in middle aged mice this leads to:
Chronic renal disease
Elevated BUN and creatinine
Transmitted to naïve mice by co-housing or dirty bedding transfer
In random sampling of feces from immunodeficient and immunocompetent mice we found 15.5 % of samples positive.
Mice of multiple genetic lineages tested positive, including outbred stocks, inbred strains, and immunocompromised mice.
IDEXX BioAnalytics has developed a PCR-based, MKPV assay for detection .
MKPV can be added to any profile upon request or ordered as a stand-along PCR test
A serologic assay for MKPV detection is under development
Sample types for PCR detection.
Feces from the cage